REFERENCES

Entanglement of polymer chains in hypertonic medium enhances the delivery of DNA and other biomacromolecules into cells

Aneta Karpińska, Alicja Zgorzelska, Karina Kwapiszewska, Robert Hołyst
Most experimental procedures applied in modern biology involve cargo delivering into cells. One of the ways to cargo introduction is osmotic-mediated intracellular vesicle swelling. However, its widespread use was hindered due to cargo size (<10 nm) and cell-type-related restrictions. We addressed the issue of the composition of colloidal loading solution to enhance the efficiency of cellular delivery.

Quantitative analysis of biochemical processes in living cells at a single-molecule level

Aneta Karpińska, Marta Pilz, Joanna Buczkowska, Paweł J. Żuk, Karolina Kucharska, Gaweł Magiera, Karina Kwapiszewska and Robert Hołyst
Quantitative description of biochemical processes inside living cells and at single-molecule levels remains a challenge at the forefront of modern instrumentation and spectroscopy. This paper demonstrates such single-cell, single-molecule analyses performed to study the mechanism of action of olaparib – an up-to-date, FDA-approved drug for germline-BRCA mutated metastatic breast cancer.

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